Products & Services
XenoAptamers
Xenolis provides a series of high-affinity and high-specificity XenoAptamers targeting proteins for detection, diagnostics, and therapeutics. Our target proteins are produced using the HEK293 expression system and glycosylated.
Our proprietary platform allows us to generate XenoAptamers with sub-nanomolar Kd values to unlock novel discoveries and applications.
We provide various types of XenoAptamers, including XenoAptamer bodies, mini-hairpin XenoAptamers, and modified XenoAptamers, as wll as customized ExSELEXâ„¢ selection and development services.
We utilize our many years of experience and the latest high-throughput, automated technologies to deliver XenoAptamer-based solutions to the customer base for a wide range of life science applications.
Explore our new Xenolis catalogue. For more information, please contact us.
XenoAptamer List
- Length: with mini-hairpin (9-mer at the 3′ terminus)
- Size: 1 / 5 / 10 nmol or Bulk Inquiry.
- Modification: unmodified, biotin (at mini-hairpin), amino-group (at mini-hairpin), or Other Modification Inquiry.
XenoAptamer Molecular Affinity Ruler
Xenolis offers a collection of XenoAptamers with diverse Kd values for the same targets. This molecular affinity ruler set is beneficial for evaluating and enhancing aptamer applicability in diagnostic device developments and drug assessments. By substituting UBs in XenoAptamers with natural bases, a set of XenoAptamers with various Kd values can be created. Explore our new Xenolis catalogue. For more information, please contact us.
Anti-VEGF165 XenoAptamer Set
Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA.
Anti-IFNγ XenoAptamer Set
Anti-IL8 XenoAptamer Set
Upcoming
DNA/RNA Engineering
by Genetic Alphabet Expansion
Xenolis is offering reagents for genetic alphabet expansion systems in replication and transcription. The Ds−Px pair system can be used for replication and PCR with Ds-containing DNA templates and Ds and Px substrates (dDsTP and dPxTP) using 3’-exonuclease-proficient DNA polymerases, such as DeepVent and AccuPrime™ Pfx. The Ds−Pa pair system can be used for the site-specific incorporation of functional Pa in RNA transcripts by T7 RNA polymerase using Ds-containing DNA templates and modified PaTP, such as NH2-, biotin-, and DFHBI-conjugated PaTPs.
We offer custom synthesis of DNA fragments containing Ds, as well as dDsTP, dPxTP, and various modified PaTPs, for the preparation of DNA templates. We are equipped to synthesize DNA oligonucleotides (up to 50-mer) at PAGE purification grade. For assistance with DNA design and non-natural transcription substrates, please contact us.
UB Replication Reagents
XTP-0100 (
d
DsTP)Size: 1 / 2 / 5 μmol
XTP-0101 (Diol-
d
PxTP)Size: 1 / 2 / 5 μmol
References
Highly specific unnatural base pair systems as a third base pair for PCR amplification.
UB Transcription Reagents
Modified PaTP
Size: 1 / 2 / 5 μmol
References
for
UBP transcription protocolsXTP-0201 (NH
2
-PaTP)
XTP-0202 (Biotin-PaTP)
XTP-0203 (DFHBI-PaTP)
Custom Synthesis
of
UB-containing DNAsXenolis offers DNA fragments containing Ds bases (up to 50 nucleotides in length) for use in transcription DNA templates through PCR or primer extension (Custom Template DNA Synthesis).