News & Events
24 January 2024
Our CSO, Ichiro Hirao, presented at the 1916th Zasshikai Seminar on “New Modality of DNA Aptamers Through Genetic Alphabet Expansion.” The seminar highlighted the innovative development of DNA aptamers using expanded genetic alphabets, showcasing potential applications in research and therapeutics.
25 October 2023
Our groundbreaking six-letter RNA engineering application, utilizing the combination of guanidine riboswitch and Spinach riboswitch, has been published in ACS Sensors. This innovative approach highlights our commitment to advancing RNA-based biosensor technology. <Systematic Mutation and Unnatural Base Pair Incorporation Improves Riboswitch-Based Biosensor Response Time>
07 September 2023
Discover pioneering enhancements in XenoAptamers’ binding affinities through the innovative use of hydrophobic unnatural bases, as detailed in our publication in the Journal of the American Chemical Society. <Strict Interactions of Fifth Letters, Hydrophobic Unnatural Bases, in XenoAptamers with Target Proteins>
30 March 2023
Aptamer 2023, held in Oxford, UK on March 29-30, 2023, featured Professor Ichiro Hirao as a keynote speaker. Professor Hirao discussed the advanced ExSELEX technique for generating high-affinity, six-letter DNA aptamers through the expansion of the genetic alphabet. <Speakers in Aptamer 2023>
08 March 2023
Handbook of Chemical Biology of Nucleic Acids, Published in 2023 by Springer Nature has included a chapter on the “Genetic Alphabet Expansion of Nucleic Acids”, authored by our COO, Michiko Kimoto and our CSO, Ichiro Hirao. <Read more>
13 January 2023
Our paper (Oh, J. et al. Nature Commun, 2023) presents how T7 RNA polymerase can identify and integrate our unnatural Ds and Pa base pairs into RNA. This discovery advances the capabilities of genetic engineering and synthetic biology.