News & Events
14-16 October 2024
Our CSO, Ichiro Hirao, presented a special lecture at the 1st International Symposium on Living Systems Design Research ↗ on “Genetic alphabet expansion for novel living systems.”
2-6 September 2024
Our COO, Michiko Kimoto, presented at IRT2024 Tokyo (XXV International Round Table on Nucleosides, Nucleotides, and Nucleic Acids) ↗ on “Six-Letter DNA Aptamer Generation as an Antibody Alternative.”
24 January 2024
Our CSO, Ichiro Hirao, presented at the 1916th Zasshikai Seminar ↗ on “New Modality of DNA Aptamers Through Genetic Alphabet Expansion.” The seminar highlighted the innovative development of DNA aptamers using expanded genetic alphabets, showcasing potential applications in research and therapeutics.
23-24 November 2023
Our CSO, Ichiro Hirao presented at FNA Perth 2023 ↗ on ExSELEX for high-affinity six-letter DNA aptamer generation by genetic alphabet expansion.
25 October 2023
Our groundbreaking six-letter RNA engineering application, utilizing the combination of guanidine riboswitch and Spinach riboswitch, has been published in ACS Sensors. This innovative approach highlights our commitment to advancing RNA-based biosensor technology. <Systematic Mutation and Unnatural Base Pair Incorporation Improves Riboswitch-Based Biosensor Response Time> ↗
07 September 2023
Discover pioneering enhancements in XenoAptamers’ binding affinities through the innovative use of hydrophobic unnatural bases, as detailed in our publication in the Journal of the American Chemical Society. <Strict Interactions of Fifth Letters, Hydrophobic Unnatural Bases, in XenoAptamers with Target Proteins> ↗
30 March 2023
Aptamer 2023, held in Oxford, UK on March 29-30, 2023, featured Professor Ichiro Hirao as a keynote speaker. Professor Hirao discussed the advanced ExSELEX technique for generating high-affinity, six-letter DNA aptamers through the expansion of the genetic alphabet. <Speakers in Aptamer 2023> ↗
08 March 2023
Handbook of Chemical Biology of Nucleic Acids, Published in 2023 by Springer Nature has included a chapter on the “Genetic Alphabet Expansion of Nucleic Acids”, authored by our COO, Michiko Kimoto and our CSO, Ichiro Hirao. <Read more> ↗
13 January 2023
Our paper (Oh, J. et al. Nature Commun, 2023 ↗ ) presents how T7 RNA polymerase can identify and integrate our unnatural Ds and Pa base pairs into RNA. This discovery advances the capabilities of genetic engineering and synthetic biology.